Clark John, Whitelaw Bruce
Department of Gene Expression and Development, Roslin Institute, Roslin, Midlothian EH25 9PS, UK.
Nat Rev Genet. 2003 Oct;4(10):825-33. doi: 10.1038/nrg1183.
The techniques that are used to generate transgenic livestock are inefficient and expensive. This, coupled with the fact that most agriculturally relevant traits are complex and controlled by more than one gene, has restricted the use of transgenic technology. New methods for modifying the genome will underpin a resurgence of research using transgenic livestock. This will not only increase our understanding of basic biology in commercial species, but might also lead to the generation of animals that are more resistant to infectious disease.
用于培育转基因家畜的技术效率低下且成本高昂。再加上大多数与农业相关的性状都很复杂,且受多个基因控制,这限制了转基因技术的应用。修改基因组的新方法将为利用转基因家畜开展的研究复兴奠定基础。这不仅会增进我们对商业物种基础生物学的理解,还可能培育出对传染病更具抵抗力的动物。