Marsh S J, Dolson G M
Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Ren Fail. 1995 Jul;17(4):475-8. doi: 10.3109/08860229509037611.
Severe adverse reactions to neuroleptic medications are not uncommon and include the neuroleptic malignant syndrome, rhabdomyolysis, and acute renal failure. The neuroleptic malignant syndrome consists of hyperthermia, diaphoresis, tachycardia, tachypnea, abnormal blood pressure, alteration of consciousness, and extrapyramidal rigidity. Rhabdomyolysis--which might be due to hyperthermia, muscle rigidity, and/or metabolic changes in skeletal muscle function--results in acute renal failure. We report a patient with rhabdomyolysis and acute renal failure that developed after large doses of haloperidol were given, but without muscle rigidity or hyperthermia. This patient's presentation illustrates that high-dose haloperidol therapy might cause rhabdomyolysis and acute renal failure without significant rigidity or hyperthermia.
抗精神病药物的严重不良反应并不罕见，包括抗精神病药物恶性综合征、横纹肌溶解症和急性肾衰竭。抗精神病药物恶性综合征包括高热、多汗、心动过速、呼吸急促、血压异常、意识改变和锥体外系僵硬。横纹肌溶解症（可能由于高热、肌肉僵硬和/或骨骼肌功能的代谢变化所致）会导致急性肾衰竭。我们报告了一名患者，在给予大剂量氟哌啶醇后出现横纹肌溶解症和急性肾衰竭，但无肌肉僵硬或高热。该患者的表现说明高剂量氟哌啶醇治疗可能会导致横纹肌溶解症和急性肾衰竭，而无明显的僵硬或高热。
