Román O, Barrera R, Bunout D, Martínez D, Cuevas G
Departamento de Medicina, Facultad de Medicina, Universidad de Chile, Hospital Clínico San Borja Arriarán, Santiago de Chile.
Rev Med Chil. 1995 Jan;123(1):23-7.
Insulin resistance is associated to hypertension, obesity and diabetes and may be an independent cardiovascular risk factor. The exact assessment of insulin resistance requires complex metabolic studies. However, there is a good correlation between this parameter and fasting serum insulin levels. The aim of this work was to study fasting serum insulin levels by radio immuno analysis in 43 hypertensive patients aged 56 +/- 5.5 years old (27 male, 17 obese and 8 diabetics) and 20 normotensive controls aged 50 +/- 4.8 years old (13 male). Insulin levels were 3.8 UI/L in controls, 12.1 UI/L in normal weight, 15.5 UI/L in obese and 18.3 UI/L in diabetic hypertensives (ANOVA p < 0.001). These levels were above two standard deviations of control values in 50% of normal weight, 66% of obese and 62% of diabetic hypertensives. It is concluded that normal weight, obese and diabetic hypertensive subjects have high fasting insulin levels.
胰岛素抵抗与高血压、肥胖和糖尿病相关，可能是一个独立的心血管危险因素。胰岛素抵抗的准确评估需要复杂的代谢研究。然而，该参数与空腹血清胰岛素水平之间存在良好的相关性。本研究的目的是通过放射免疫分析研究43例年龄为56±5.5岁的高血压患者（27例男性，17例肥胖，8例糖尿病患者）和20例年龄为50±4.8岁的血压正常对照组（13例男性）的空腹血清胰岛素水平。对照组胰岛素水平为3.8 UI/L，正常体重者为12.1 UI/L，肥胖者为15.5 UI/L，糖尿病高血压患者为18.3 UI/L（方差分析p<0.001）。在50%的正常体重者、66%的肥胖者和62%的糖尿病高血压患者中，这些水平高于对照值的两个标准差。结论是正常体重、肥胖和糖尿病高血压患者空腹胰岛素水平较高。
