Ohnishi A, Mori K, Fujishiro K, Kohriyama K, Miyata M, Murai Y, Ikeda M
Department of Neurology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
J UOEH. 1995 Sep 1;17(3):165-72. doi: 10.7888/juoeh.17.165.
Three neurobehavioral tests and a profile of mood states (POMS) test, which are included in the WHO neurobehavioral core test battery, were applied to 106 workers engaged in manufacturing automotive parts, especially for the purpose of determining the presence or absence of a significant difference in the score between a group of sixty-one workers chronically exposed to organic solvents and a group of forty-five workers unexposed. The scores of both pursuit-aiming and digit-symbol substitution tests were lower (P < 0.02 and P < 0.01, respectively, in analysis of covariance) in the group of exposed workers than in the group of unexposed workers. Furthermore, in the group of exposed workers, the pursuit-aiming and digit-symbol substitution scores showed a positive correlation (P < 0.05 and P < 0.01, respectively) to the fatigue score in the POMS test. On the other hand, the score of the digit span test showed no significant difference between the two groups. No significant correlation was found between the urinary hippuric acid level and the score of each of the three neurobehavioral tests. Therefore, among the exposed workers, the perceptual motor function evaluated in pursuit-aiming and digit-symbol tests seems to be affected. The neurobehavioral tests administered in this study are limited in number and in function, however, the comparison of their scores between the exposed and unexposed workers may suggest the presence of adversive effects of chronic exposure to organic solvents.
世界卫生组织神经行为核心测试组中的三项神经行为测试和一项情绪状态量表（POMS）测试，被应用于106名从事汽车零部件制造的工人，特别是为了确定61名长期接触有机溶剂的工人组和45名未接触有机溶剂的工人组在得分上是否存在显著差异。在协方差分析中，接触组工人的追踪瞄准测试和数字符号替换测试得分均低于未接触组工人（分别为P < 0.02和P < 0.01）。此外，在接触组工人中，追踪瞄准和数字符号替换得分与POMS测试中的疲劳得分呈正相关（分别为P < 0.05和P < 0.01）。另一方面，数字广度测试得分在两组之间没有显著差异。尿马尿酸水平与三项神经行为测试中每项测试的得分之间均未发现显著相关性。因此，在接触组工人中，追踪瞄准和数字符号测试中评估的感知运动功能似乎受到了影响。本研究中进行的神经行为测试在数量和功能上都有限，然而，接触组和未接触组工人得分的比较可能表明长期接触有机溶剂存在不良影响。
