Popovic E A, Kaye A H, Hill J S
Department of Neurosurgery, Melbourne Neuroscience Centre, Royal Melbourne Hospital, Victoria, Australia.
Semin Surg Oncol. 1995 Sep-Oct;11(5):335-45. doi: 10.1002/ssu.2980110503.
Photodynamic therapy (PDT) is a binary treatment modality suitable for various malignant tumors including brain. It involves the selective uptake of a photosensitizer into tumor followed by intraoperative irradiation of the tumor with light of an appropriate wavelength to cause activation of the sensitizer and subsequent selective tumor destruction. PDT has been extensively investigated in laboratory studies and has been used in clinical trials to treat a variety of brain tumors, particularly gliomas. The main advantage of PDT lies in its ability to select out infiltrating tumor cells that are responsible for local tumor recurrence. The therapy has been shown to be safe clinically but adequate trials have yet to be undertaken to prove its efficacy and much work remains to be done to optimize treatment. The biological basis, laboratory studies, and clinical trials involving PDT in the treatment of cerebral tumors are discussed.
光动力疗法（PDT）是一种适用于包括脑肿瘤在内的各种恶性肿瘤的二元治疗方式。它包括将光敏剂选择性地摄取到肿瘤中，然后在术中用适当波长的光照射肿瘤，以激活光敏剂并随后选择性地破坏肿瘤。光动力疗法已在实验室研究中得到广泛研究，并已用于临床试验以治疗各种脑肿瘤，特别是神经胶质瘤。光动力疗法的主要优点在于其能够筛选出导致局部肿瘤复发的浸润性肿瘤细胞。该疗法在临床上已被证明是安全的，但尚未进行充分的试验来证明其疗效，并且在优化治疗方面仍有许多工作要做。本文讨论了光动力疗法治疗脑肿瘤的生物学基础、实验室研究和临床试验。
