Popovic E A, Kaye A H, Hill J S
Department of Neurosurgery, Melbourne Neuroscience Centre, Royal Melbourne Hospital, Victoria, Australia.
J Clin Laser Med Surg. 1996 Oct;14(5):251-61. doi: 10.1089/clm.1996.14.251.
Photodynamic therapy (PDT) for the treatment of a variety of brain tumors, particularly gliomas, has been extensively investigated in laboratory studies and has been studied in clinical trials. The main advantage of PDT lies in its ability to select out tumor cells that are infiltrating brain parenchyma and that are responsible for local tumor recurrence, the major therapeutic dilemma in the treatment of gliomas. PDT has been shown to be safe clinically but adequate trials have yet to be undertaken to prove its efficacy and much work remains to be done to optimize treatment. The laboratory studies and clinical trials involving PDT in the treatment of cerebral tumors, particularly the commonest brain tumors, gliomas, are discussed.
光动力疗法（PDT）用于治疗多种脑肿瘤，尤其是胶质瘤，已在实验室研究中得到广泛研究，并已进入临床试验阶段。PDT的主要优势在于它能够筛选出浸润脑实质并导致局部肿瘤复发的肿瘤细胞，而这正是胶质瘤治疗中的主要治疗难题。临床研究表明PDT是安全的，但仍需进行充分的试验以证明其疗效，并且在优化治疗方面仍有许多工作要做。本文将讨论涉及PDT治疗脑肿瘤，特别是最常见的脑肿瘤——胶质瘤的实验室研究和临床试验。
