Caronti B, Palladini G, Calderaro C, Bevilacqua M G, Petrangeli E, Esposito V, Tamburrano G, Gulino A, Jaffrain-Rea M L
Department of Neurological Sciences, University La Sapienza, Italy.
Tumour Biol. 1995;16(6):353-64. doi: 10.1159/000217952.
The effects of testosterone (T), dihydrotestosterone (DHT) and methyltrienolone (R 1881) on cell proliferation of eight human pituitary tumors in culture wre assessed by [3H]thymidine incorporation and compared to those of progesterone (Pg) and 17 beta-estradiol. Receptors for androgens (AR), estrogens (ER) and progesterone (PgR) were characterized. AR had a significant inhibitory effect on all AR-positive tumors, whatever their hormonal content. Inhibitory effects of either T and DHT < R1881 < Pg were observed in tumors co-expressing AR and PgR. The inhibitory effect of R 1881 on a PgR-positive/AR-negative tumor suggested that R 1881 action was partially PgR-mediated. The effects of either T or the nonaromatizable DHT and R 1881 were unrelated to ER expression. We conclude that AR can modulate the growth of human pituitary tumors through direct receptor-mediated intracellular pathways which may be common to various pituitary cell types.
通过[3H]胸腺嘧啶核苷掺入法评估了睾酮（T）、双氢睾酮（DHT）和甲基三烯olone（R1881）对培养的8种人垂体肿瘤细胞增殖的影响，并与孕酮（Pg）和17β-雌二醇的影响进行了比较。对雄激素受体（AR）、雌激素受体（ER）和孕酮受体（PgR）进行了表征。AR对所有AR阳性肿瘤均有显著抑制作用，无论其激素含量如何。在共表达AR和PgR的肿瘤中，观察到T和DHT的抑制作用＜R1881＜Pg。R1881对PgR阳性/AR阴性肿瘤的抑制作用表明，R1881的作用部分由PgR介导。T或不可芳香化的DHT和R1881的作用与ER表达无关。我们得出结论，AR可以通过直接的受体介导的细胞内途径调节人垂体肿瘤的生长，这些途径可能是各种垂体细胞类型所共有的。
