Favre H
Division de néphrologie, Hôpital Cantonal Universitaire, Genève.
Rev Prat. 1995 Sep 1;45(13):1638-42.
Tubular necrosis is the most frequent hospital-acquired cause of acute renal failure from renal origin. The two main factors leading to tubular necrosis are hemodynamic perturbations and use of nephrotoxic agents. There is recently a growing number of reports on tubular necrosis associated with a non traumatic rhabdomyolysis. In 60-70% of the cases, more than one contributing factor can be identified. In the majority of the patients who developed a transient postoperative acute renal failure, co-morbid factors such as diabetes, hypertension or major cardiovascular problems, are present. Acute renal failure increases the mortality by factors from 2-7. Therefore prevention and (or) early correction of the factors leading to tubular necrosis are of great importance.
肾小管坏死是医院获得性急性肾衰竭最常见的肾脏源性病因。导致肾小管坏死的两个主要因素是血流动力学紊乱和使用肾毒性药物。最近，关于非创伤性横纹肌溶解相关的肾小管坏死的报道越来越多。在60%-70%的病例中，可以确定不止一个促成因素。在大多数发生短暂术后急性肾衰竭的患者中，存在糖尿病、高血压或重大心血管问题等合并症因素。急性肾衰竭会使死亡率增加2至7倍。因此，预防和（或）早期纠正导致肾小管坏死的因素非常重要。
