Chiaramonte M, Ngatchu T, Majori S, Baldo V, Moschen M E, Renzulli G, Trivello R
Institute of Hygiene, University of Padua, Italy.
Scand J Gastroenterol. 1995 Jun;30(6):601-3. doi: 10.3109/00365529509089796.
In a campaign to vaccinate health care workers, a three-dose schedule (0, 1, and 6 months) and a four-dose schedule (0, 1, 2, and 14 months) with hepatitis B (HB) vaccine were used. After primary immunization 26 subjects vaccinated with the 3-dose schedule and 4 subjects vaccinated with the 4-dose schedule had undetectable anti-HBs titres.
All these 30 non-responders received an extra dose of the same vaccine 2 months after primary immunization and a booster dose with a yeast-derived vaccine 6 years later. Anti-HBs levels were evaluated 1 month after the extra dose and after the booster dose.
One month after the extra dose 26.9% (7 of 26) of the subjects vaccinated with the 3-dose schedule became positive for anti-HBs. Six years later only two of these subjects had detectable anti-HBs. After the booster dose the seven subjects who responded to the extra dose showed an anamnestic type of response, and five additional subjects became positive for anti-HBs. Responders to the extra dose were significantly younger than the non-responders. In the four-dose group only one subject responded to the extra dose, and that subject maintained protective anti-HBs.
About 25% of non-responders to primary HB vaccination could benefit from an extra dose, and these subjects show an anamnestic type of response to HBs antigen even after 6 years. This response seems to be influenced by age.
在一项医护人员乙肝疫苗接种活动中，采用了乙肝（HB）疫苗的三剂次接种程序（0、1和6个月）和四剂次接种程序（0、1、2和14个月）。初次免疫后，26名采用三剂次接种程序接种的受试者和4名采用四剂次接种程序接种的受试者抗-HBs滴度检测不到。
所有这30名无应答者在初次免疫后2个月额外接种一剂相同疫苗，并在6年后接种一剂酵母衍生疫苗作为加强针。在额外接种一剂疫苗后1个月以及接种加强针后评估抗-HBs水平。
在额外接种一剂疫苗后1个月，26.9%（26名中的7名）采用三剂次接种程序接种的受试者抗-HBs转为阳性。6年后，这些受试者中只有2人抗-HBs可检测到。接种加强针后，对额外接种疫苗有反应的7名受试者表现出回忆性反应类型，另有5名受试者抗-HBs转为阳性。对额外接种疫苗有反应的受试者明显比无反应者年轻。在四剂次接种组中，只有1名受试者对额外接种疫苗有反应，且该受试者维持了保护性抗-HBs水平。
约25%的乙肝初次接种无应答者可从额外接种一剂疫苗中获益，这些受试者即使在6年后对HBs抗原仍表现出回忆性反应类型。这种反应似乎受年龄影响。
