Arigoni F, Pogliano K, Webb C D, Stragier P, Losick R
Institut de Biologie Physico-Chimique, Paris, France.
Science. 1995 Oct 27;270(5236):637-40. doi: 10.1126/science.270.5236.637.
Asymmetric division in Bacillus subtilis generates progeny cells with dissimilar fates. SpoIIE, a membrane protein required for the establishment of cell type, was shown to localize near sites of potential polar division. SpoIIE initially localizes in a bipolar pattern, coalescing at marks in the cell envelope at which asymmetric division can take place. Then, during division, SpoIIE becomes restricted to the polar septum and is lost from the distal pole. Thus, when division is complete, SpoIIE sits at the boundary between the progeny from which it dictates cell fate by the activation of a cell-specific transcription factor.
枯草芽孢杆菌中的不对称分裂产生具有不同命运的子代细胞。SpoIIE是一种建立细胞类型所需的膜蛋白，已被证明定位于潜在极性分裂位点附近。SpoIIE最初以双极模式定位，在细胞膜上不对称分裂可能发生的标记处合并。然后，在分裂过程中，SpoIIE局限于极性隔膜，并从远端极消失。因此，当分裂完成时，SpoIIE位于子代之间的边界处，它通过激活细胞特异性转录因子来决定细胞命运。
