[白细胞介素-1β对离体大鼠胰岛胰岛素释放的抑制作用及睾酮的逆转作用]
[Inhibitory effect of interleukin-1 beta on insulin release from isolated rat pancreatic islets and the reversal action of testosterone].
作者信息
Fang H L, Wang L, Yang Y K, Zhu W Y
机构信息
Department of Physiology, Beijing Medical University.
出版信息
Sheng Li Xue Bao. 1995 Jun;47(3):264-8.
PMID:7570112
Abstract
Insulin release from pancreatic islet cells of neonatal rats could be markedly inhibited by a previous incubation of cells with interleukin-1 beta (5-20 U/ml) for 20 h even under high glucose (20 mmol/L) stimulation. This inhibitory effect of IL-1 beta on insulin release could be reversed by testosterone (10(-10) mol/L), which was accompanied by an increase of the insulin content in islet cells.
摘要
即使在高糖（20 mmol/L）刺激下，新生大鼠胰岛细胞预先与白细胞介素-1β（5 - 20 U/ml）孵育20小时，其胰岛素释放也会受到显著抑制。睾酮（10⁻¹⁰ mol/L）可逆转白细胞介素-1β对胰岛素释放的这种抑制作用，同时胰岛细胞中的胰岛素含量会增加。
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