Fok C M, Reynolds V B, Tan K A, Ong C L, Chong P Y
Department of Diagnostic Imaging, National University Hospital, Singapore.
Singapore Med J. 1995 Feb;36(1):29-31.
Over a period of two and a half years, 36 biopsies performed for clustered microcalcifications not associated with a mass revealed 30 benign and 6 malignant lesions. Of the 30 benign cases, 4 showed histological features which are thought to be associated with an increased risk of developing carcinoma. As similarities can exist in the mammographic appearances between benign and malignant microcalcifications, clusters of microcalcifications showing overlapping features or increasing in number over time require histopathologic study as there is no radiologic means at present of predicting which cluster will be malignant. We observe that our Chinese female population has a tendency towards dense breast parenchyma often associated with microcalcifications, both scattered and clustered. The presence of these clustered microcalcifications prompts biopsy even though the yield for malignancy is anticipated to be low.
在两年半的时间里，对36例与肿块无关的成簇微小钙化灶进行活检，结果显示有30例为良性病变，6例为恶性病变。在30例良性病例中，有4例显示出被认为与患癌风险增加相关的组织学特征。由于良性和恶性微小钙化灶的乳腺X线表现可能存在相似之处，对于表现出重叠特征或随时间增多的微小钙化灶簇，需要进行组织病理学研究，因为目前尚无放射学方法能够预测哪些簇状钙化灶会发展为恶性。我们观察到，我们的中国女性人群往往存在乳腺实质致密的倾向，且常伴有散在和簇状的微小钙化灶。尽管预计恶性病变的活检阳性率较低，但这些簇状微小钙化灶的存在仍促使进行活检。
