Isolated clustered microcalcifications in the breast: radiologic-pathologic correlation.

Thirty-one consecutive cases of mammographic isolated, clustered microcalcifications which prompted breast biopsy were studied by radiologic and histopathologic methods. Isolated, clustered microcalcifications were sensitive, but nonspecific cancer markers; 35% of the lesions were malignant and half of these were noninvasive. Radiologic and histopathologic similarities, and overlap between benign and malignant disease, prevented accurate differentiation. Breast biopsy is indicated when isolated, clustered microcalcifications are discovered by mammography.