基于生理学的药代动力学和药效学建模在健康风险评估及有害物质特性描述中的应用

Physiologically based pharmacokinetic and pharmacodynamic modeling in health risk assessment and characterization of hazardous substances.

作者信息

Leung H W, Paustenbach D J

机构信息

Union Carbide Corporation, Danbury, CT 06817, USA.

出版信息

Toxicol Lett. 1995 Sep;79(1-3):55-65. doi: 10.1016/0378-4274(95)03357-q.

DOI:10.1016/0378-4274(95)03357-q

PMID:7570674

Abstract

Recent advances in physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) modeling have introduced novel approaches for evaluating toxicological problems. Because PBPK models are amenable to extrapolation of tissue dosimetry, they are increasingly being applied to chemical risk assessment. A comprehensive listing of PBPK/PD models for environmental chemicals developed to date is referenced. Salient applications of PBPK/PD modeling to health risk assessments and characterization of hazardous substances are illustrated with examples.

摘要

基于生理学的药代动力学和药效学（PBPK/PD）模型的最新进展引入了评估毒理学问题的新方法。由于PBPK模型适用于组织剂量测定的外推，它们越来越多地应用于化学风险评估。文中引用了迄今为止开发的环境化学品PBPK/PD模型的综合列表。通过实例说明了PBPK/PD模型在健康风险评估和有害物质表征方面的显著应用。