Yamakawa A, Tanaka E, Nakano S
Department of physiology, Tokai University School of Medicine, Kanagawa, Japan.
Tokai J Exp Clin Med. 1994 Dec;19(3-6):139-42.
Heat production by isolated brown adipocytes, from hypothalamic obese rats and from older rats, was investigated by microcalorimetry. The obese and older rats were 12 and 40 weeks-old, respectively. The basal heat production by the brown adipocytes was significantly less in the obese and older rats than in control rats 12 weeks of age. Isoproterenol and a novel adrenergic beta 3-agonist, BRL37344, increased heat production in a concentration-dependent manner in all rats. The effects of isoproterenol were significantly less in the obese group than in the controls, while BRL37344 stimulated heat production in all rats almost identically. These results suggest that (1) the heat producing capacity of brown adipocytes is reduced by hypothalamic obesity and aging, and (2) BRL37344 might be useful as an anti-obesity drug.
采用微量量热法研究了下丘脑性肥胖大鼠和老年大鼠分离出的棕色脂肪细胞的产热情况。肥胖大鼠和老年大鼠分别为12周龄和40周龄。肥胖大鼠和老年大鼠棕色脂肪细胞的基础产热显著低于12周龄的对照大鼠。异丙肾上腺素和一种新型肾上腺素β3-激动剂BRL37344在所有大鼠中均以浓度依赖性方式增加产热。异丙肾上腺素对肥胖组的作用明显小于对照组，而BRL37344对所有大鼠产热的刺激作用几乎相同。这些结果表明：（1）下丘脑性肥胖和衰老会降低棕色脂肪细胞的产热能力；（2）BRL37344可能作为一种抗肥胖药物。
