Boudi A, Zaparucha A, Galons H, Chiadmi M, Viossat B, Tomas A, Fiet J
Laboratoire de biologie hormonale, Hôpital Saint Louis, Paris, France.
Steroids. 1995 May;60(5):411-3. doi: 10.1016/0039-128x(94)00075-n.
The photochemical hypoiodination of cortisol acetonide gave a mixture of 18-iodocortisol acetonide and of the 11 beta,19-oxidoderivative. The proportion of the two products was slightly modified by the reaction temperature. Deprotection of the acetonide group of the 11 beta,19-oxidoderivative gave 11 beta,19-oxido-17 alpha,21-dihydroxy-4-pregnen-3,20-dione which led to the formation of 11 beta,19-oxido-4-androsten-3,17-dione upon treatment with sodium bismutate.
皮质醇丙酮化物的光化学低碘化反应产生了18-碘代皮质醇丙酮化物和11β,19-氧化衍生物的混合物。两种产物的比例会因反应温度而略有改变。11β,19-氧化衍生物的丙酮基脱保护得到11β,19-氧化-17α,21-二羟基-4-孕烯-3,20-二酮，用铋酸钠处理后会形成11β,19-氧化-4-雄烯-3,17-二酮。
