Diatta G, Trape J F, Legros F, Rogier C, Duplantier J M
Laboratoire de Paludologie, ORSTOM, Dakar, Sénégal.
Trans R Soc Trop Med Hyg. 1994 Jul-Aug;88(4):423-4. doi: 10.1016/0035-9203(94)90412-x.
In a rural area in Sénégal with a high incidence of tick-borne relapsing fever in humans, Borrelia crocidurae was studied in the blood and brain of wild rodents (Mastomys erythroleucus, Arvicanthis niloticus and Rattus rattus) using 3 methods: (i) direct examination of thick blood films; (ii) intraperitoneal inoculation of blood into white mice; (iii) intraperitoneal inoculation of homogenized cerebral tissue into white mice. Of the 82 rodents examined, the proportion of infected animals was respectively 2.4%, 7.3% and 14.6% for each method, and 18.3% for all 3 methods combined. Of the 12 animals with infected cerebral tissue, only 3 were found to have infected blood. These results suggest that isolated infections of the brain occur frequently in Senegalese wild rodents. Measurement of the real prevalence of B. crocidurae should therefore take into account these infections in addition to blood infections.
在塞内加尔一个人类蜱传回归热发病率很高的农村地区，利用三种方法对野生啮齿动物（红背鼠、尼罗多齿稻鼠和黑家鼠）的血液和大脑中的伯氏疏螺旋体进行了研究：（i）直接检查厚血膜；（ii）将血液腹腔接种到小白鼠体内；（iii）将匀浆化的脑组织腹腔接种到小白鼠体内。在所检查的82只啮齿动物中，每种方法检测到的感染动物比例分别为2.4%、7.3%和14.6%，三种方法综合检测时为18.3%。在12只脑组织被感染的动物中，仅发现3只有感染的血液。这些结果表明，在塞内加尔野生啮齿动物中，脑部的孤立感染很常见。因此，对伯氏疏螺旋体实际患病率的测量除了血液感染外，还应考虑这些感染情况。
