Sasagawa I, Nakada T, Ishigooka M, Tomaru M, Sawamura T, Tateno T
Department of Urology, Yamagata University School of Medicine, Japan.
Urol Int. 1995;55(1):25-8. doi: 10.1159/000282742.
Identification of marker chromosomes by fluorescence in situ hybridization was performed in 2 cases of cryptorchidism. In case 1, the marker chromosome was derived from chromosome 22. In case 2, the origin of the marker was the centromere of chromosome 8. The extent of the congenital anomalies in these cases was milder than that in cases with complete trisomy of an autosome. These findings suggest that an incomplete extra autosome might influence clinical characteristics.
采用荧光原位杂交技术对2例隐睾症患者进行标记染色体鉴定。病例1中，标记染色体来源于22号染色体。病例2中，标记染色体的起源是8号染色体的着丝粒。这些病例中先天性异常的程度比常染色体完全三体病例中的程度要轻。这些发现表明，一条不完整的额外常染色体会影响临床特征。
