Sheth N V, Dell'Osso L F, Leigh R J, Van Doren C L, Peckham H P
Ocular Motor Neurophysiology Laboratory, Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA.
Vision Res. 1995 Aug;35(16):2371-82. doi: 10.1016/0042-6989(94)00321-c.
Visual acuity in congenital nystagmus (CN) patients is related primarily to the duration of "foveation periods", during which the image of the target is relatively stationary in the foveal area. Thirteen individuals with CN were studied to test the hypothesis that somatosensory stimulation (vibration or electrical) of either the forehead or the neck damps CN and improves visual acuity. We identified characteristics of the nystagmus waveform that were likely to be important in determining visual acuity and combined these measures into an "acuity function" (NAFP) that correlated well with visual acuity (r2 = 0.91). Statistically significant changes in NAFP were used to assess the effects of afferent stimulation; positive effects were found in nine subjects. Vibratory stimulation (especially on the neck) was found to be more effective than electrical stimulation. CN amplitude reduction alone was neither necessary nor sufficient to improve acuity. Foveation duration was the single most important factor determining acuity. Based on our findings, afferent stimulation should be considered as an alternative or additional treatment to improve visual acuity in CN patients.
先天性眼球震颤（CN）患者的视力主要与“注视期”的时长有关，在此期间，目标图像在中央凹区域相对静止。对13名CN患者进行了研究，以检验以下假设：对前额或颈部进行体感刺激（振动或电刺激）可抑制CN并提高视力。我们确定了眼球震颤波形中可能对确定视力很重要的特征，并将这些测量值组合成一个“视力函数”（NAFP），该函数与视力具有良好的相关性（r2 = 0.91）。NAFP的统计学显著变化用于评估传入刺激的效果；在9名受试者中发现了积极效果。发现振动刺激（尤其是对颈部）比电刺激更有效。单纯降低CN幅度既不是提高视力的必要条件也不是充分条件。注视持续时间是决定视力的唯一最重要因素。基于我们的研究结果，传入刺激应被视为改善CN患者视力的一种替代或补充治疗方法。
