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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Monshouwer M, Witkamp R F, Nijmeijer S M, Pijpers A, Verheijden J H, Van Miert A S

Department of Veterinary Basic Sciences, University of Utrecht, The Netherlands.

Xenobiotica. 1995 May;25(5):491-9. doi: 10.3109/00498259509061868.

In order to investigate the effect of a bacterial acute phase response model on drug disposition in vivo, plasma clearances of antipyrine, caffeine, paracetamol and indocyanine green were investigated in the healthy and Actinobacillus pleuropneumoniae-infected pig. 2. Indocyanine green plasma and endogenous creatinine clearance were not changed during the infection, which indicates that hepatic blood flow and renal function were not significantly affected. 3. In the A. pleuropneumoniae-infected pig, plasma clearances of antipyrine and caffeine, both marker substrates for hepatic oxidative biotransformation, were decreased by 72 and 68% respectively. The clearance of paracetamol, a drug mainly glucuronidated in the pig, was reduced by 39%. 4. It is concluded that the most important change in drug elimination during an acute phase response induced by A. pleuropneumoniae is a suppression of oxidative hepatic biotransformation.

为研究细菌急性期反应模型对体内药物处置的影响，在健康猪和感染胸膜肺炎放线杆菌的猪中，研究了安替比林、咖啡因、对乙酰氨基酚和吲哚菁绿的血浆清除率。2. 感染期间吲哚菁绿血浆清除率和内源性肌酐清除率未发生变化，这表明肝血流量和肾功能未受到显著影响。3. 在感染胸膜肺炎放线杆菌的猪中，作为肝氧化生物转化标志物底物的安替比林和咖啡因的血浆清除率分别降低了72%和68%。猪体内主要经葡萄糖醛酸化代谢的对乙酰氨基酚的清除率降低了39%。4. 得出结论，胸膜肺炎放线杆菌诱导的急性期反应期间，药物消除的最重要变化是肝氧化生物转化受到抑制。

Monshouwer M, Witkamp R F, Nijmeijer S M, Pijpers A, Verheijden J H, Van Miert A S

Department of Veterinary Basic Sciences, University of Utrecht, The Netherlands.

Xenobiotica. 1995 May;25(5):491-9. doi: 10.3109/00498259509061868.

In order to investigate the effect of a bacterial acute phase response model on drug disposition in vivo, plasma clearances of antipyrine, caffeine, paracetamol and indocyanine green were investigated in the healthy and Actinobacillus pleuropneumoniae-infected pig. 2. Indocyanine green plasma and endogenous creatinine clearance were not changed during the infection, which indicates that hepatic blood flow and renal function were not significantly affected. 3. In the A. pleuropneumoniae-infected pig, plasma clearances of antipyrine and caffeine, both marker substrates for hepatic oxidative biotransformation, were decreased by 72 and 68% respectively. The clearance of paracetamol, a drug mainly glucuronidated in the pig, was reduced by 39%. 4. It is concluded that the most important change in drug elimination during an acute phase response induced by A. pleuropneumoniae is a suppression of oxidative hepatic biotransformation.

为研究细菌急性期反应模型对体内药物处置的影响，在健康猪和感染胸膜肺炎放线杆菌的猪中，研究了安替比林、咖啡因、对乙酰氨基酚和吲哚菁绿的血浆清除率。2. 感染期间吲哚菁绿血浆清除率和内源性肌酐清除率未发生变化，这表明肝血流量和肾功能未受到显著影响。3. 在感染胸膜肺炎放线杆菌的猪中，作为肝氧化生物转化标志物底物的安替比林和咖啡因的血浆清除率分别降低了72%和68%。猪体内主要经葡萄糖醛酸化代谢的对乙酰氨基酚的清除率降低了39%。4. 得出结论，胸膜肺炎放线杆菌诱导的急性期反应期间，药物消除的最重要变化是肝氧化生物转化受到抑制。