Min Y G, Kim Y K, Jeong S Y
Department of Otorhinolaryngology, Seoul National University College of Medicine, Korea.
Acta Otolaryngol. 1995 Jul;115(4):548-52. doi: 10.3109/00016489509139365.
To evaluate the therapeutic effects of topical antibiotic delivered by polylactic acid (PLA) polymer on paranasal sinusitis, we induced maxillary sinusitis in 32 New Zealand white rabbits by obstructing the maxillary sinus ostium and inoculating the sinus cavity with Streptococcus pneumoniae. The rabbits were divided into three groups: a control group (group 1) treated only by reopening the ostium, a group (group 2) treated by both reopening the ostium and injecting ampicillin (40 mg/kg/day), and a group (group 3) in which ampicillin in the PLA carrier (0.326 mg) was placed within the sinus after ostial patency was reestablished. The number of colony forming units (CFU) was lowest in group 3, followed by groups 2 and 1. Ampicillin concentration in the maxillary sinus secretion of group 3 was significantly higher than in group 2. The results suggest that treatment with PLA-ampicillin polymer may maintain high therapeutic concentrations of ampicillin in maxillary sinus secretion.
为评估聚乳酸（PLA）聚合物递送的局部抗生素对鼻窦炎的治疗效果，我们通过阻塞上颌窦口并在上颌窦腔内接种肺炎链球菌，在32只新西兰白兔中诱发上颌窦炎。将兔子分为三组：仅通过重新打开窦口进行治疗的对照组（第1组）；通过重新打开窦口并注射氨苄西林（40mg/kg/天）进行治疗的组（第2组）；以及在重新建立窦口通畅后将PLA载体中的氨苄西林（0.326mg）置于窦内的组（第3组）。第3组的菌落形成单位（CFU）数量最低，其次是第2组和第1组。第3组上颌窦分泌物中的氨苄西林浓度显著高于第2组。结果表明，PLA-氨苄西林聚合物治疗可能在上颌窦分泌物中维持高治疗浓度的氨苄西林。
