Min Y G, Kim Y K, Choi Y S, Shin J S, Juhn S K
Department of Otorhinolaryngology, Seoul National University College of Medicine, Korea.
Laryngoscope. 1995 Aug;105(8 Pt 1):835-42. doi: 10.1288/00005537-199508000-00013.
To evaluate the efficacy of antibiotic delivered by polyactic acid (PLA) polymer in sinusitis, we induced maxillary sinusitis in 32 New Zealand white rabbits by occluding the sinus ostium and inoculating the sinus cavity with Streptococcus pneumoniae. The rabbits were divided into three groups consisting of group 1 (control group, 8 rabbits), which was treated only by reopening the ostium; group 2, which was treated by both reopening the ostium and injecting ampicillin intramuscularly (40 mg/kg/day in three divided doses, 12 rabbits); and group 3 (12 rabbits) in which a piece of PLA-polymer ampicillin (0.326 mg) sheet (1.5 x 1.5 cm) was placed within the sinus after re-establishing ostial patency. The light microscopic findings such as epithelial ulceration, loss of cilia, infiltration of inflammatory cells, and edema were less pronounced in group 2 and minimal in group 3. The electron microscopic findings such as swelling of mitochondria and endoplasmic reticulum and protruded cytoplasm were severest in the control group, followed by groups 2 and 3. The mucociliary transport speed measured at the medial wall of the maxillary sinus was highest in group 3. The results of this study suggest that treatment with PLA-polymer ampicillin may have a better efficacy in maxillary sinusitis than that with systemic administration of ampicillin.
为评估聚乳酸（PLA）聚合物递送抗生素治疗鼻窦炎的疗效，我们通过堵塞鼻窦开口并向鼻窦腔内接种肺炎链球菌，在32只新西兰白兔中诱发上颌窦炎。将这些兔子分为三组：第1组（对照组，8只兔子），仅通过重新开放开口进行治疗；第2组，通过重新开放开口并肌肉注射氨苄西林（40mg/kg/天，分三次给药，12只兔子）进行治疗；第3组（12只兔子），在重新建立开口通畅后，将一片PLA-聚合物氨苄西林（0.326mg）薄片（1.5×1.5cm）置于鼻窦内。第2组的光镜检查结果，如上皮溃疡、纤毛丧失、炎性细胞浸润和水肿，不太明显，第3组则最小。对照组的电镜检查结果，如线粒体和内质网肿胀以及细胞质突出，最为严重，其次是第2组和第3组。在上颌窦内侧壁测量的黏液纤毛传输速度在第3组中最高。本研究结果表明，PLA-聚合物氨苄西林治疗上颌窦炎可能比全身应用氨苄西林具有更好的疗效。
