Abdul Hadi B, Török J, Mezey G
Albert Szent-Györgyi Medical University, Faculty of Pharmacy, Debrecen.
Acta Pharm Hung. 1995 May;65(3):69-75.
The history of drug registration in most developed countries has been strongly influenced by the dramatic thalidomide disaster. A systematic hand search identified all women who delivered between September 1st 1993 and June 1st 1994. A total of 2389 mothers were set against the Australian Classification of Drugs with respect to their known or suspected risks in pregnancy. According to the interview after delivery, and from the hospital files, the prescription rate of all drugs increased from 15% in period-1 (two months before pregnancy), to an average of 65.66% during pregnancy. We could divide the groups of drugs used during pregnancy into major and minor groups according to the number of women who ingested drugs in the different trimesters. 1. In the first trimester, women received major amounts of blood-forming drugs, vitamins and electrolytes, hormones, anxiolytics, antibiotics and GI drugs. 2. In the second trimester, women received major amounts of blood-forming drugs, vitamins and electrolytes, anti-infectives, anxiolytics, tocolytics and antihypertensive. 3. In the third trimester, women received major amounts of blood-forming drugs, vitamins and electrolytes, tocolytics, anxiolytics, anti-infectives, antithrombotics and antihypertensive. The drug groups mentioned above have been set according to it's decreasing use respectively.
在大多数发达国家，药品注册的历史受到沙利度胺悲剧的重大影响。通过系统的人工检索，确定了1993年9月1日至1994年6月1日期间分娩的所有女性。共有2389名母亲根据其已知或疑似的孕期风险对照澳大利亚药品分类进行了评估。根据产后访谈和医院档案，所有药物的处方率从孕期前两个月（第1阶段）的15%上升至孕期平均65.66%。我们可以根据不同孕期服用药物的女性数量，将孕期使用的药物分为主要组和次要组。1. 在孕早期，女性服用大量造血药物、维生素和电解质、激素、抗焦虑药、抗生素和胃肠道药物。2. 在孕中期，女性服用大量造血药物、维生素和电解质、抗感染药、抗焦虑药、宫缩抑制剂和抗高血压药。3. 在孕晚期，女性服用大量造血药物、维生素和电解质、宫缩抑制剂、抗焦虑药、抗感染药、抗血栓药和抗高血压药。上述药物组是根据其使用量的递减分别列出的。
