Lehotay J, Cizmárik J, Brandsteterová E
Department of Analytical Chemistry, Faculty of Chemical Technology, Slovak Technical University.
Acta Pharm Hung. 1995 May;65(3):95-6.
A HPLC method is described for the simultaneous determination of the phanylcarbamate type anesthetics heptacaine and carbisocaine and their metabolites. Using this method the in vitro degradation of these drugs in urine, human and rabbit serums was investigated. The slower degradation of carbisocaine was explained on the basis of steric hindrance.
描述了一种用于同时测定苯氨基甲酸酯类麻醉药庚卡因和卡比卡因及其代谢物的高效液相色谱法。使用该方法研究了这些药物在尿液、人和兔血清中的体外降解情况。基于空间位阻解释了卡比卡因降解较慢的原因。
