局部麻醉药的研究。第128部分。尿、人血清和兔血清中庚卡因和卡比卡因降解的高效液相色谱研究。
Study of local anesthetics. Part 128. HPLC study of the degradation of heptacaine and carbisocaine in urine, human and rabbit serums.
作者信息
Lehotay J, Cizmárik J, Brandsteterová E
机构信息
Department of Analytical Chemistry, Faculty of Chemical Technology, Slovak Technical University.
出版信息
Acta Pharm Hung. 1995 May;65(3):95-6.
PMID:7572190
Abstract
A HPLC method is described for the simultaneous determination of the phanylcarbamate type anesthetics heptacaine and carbisocaine and their metabolites. Using this method the in vitro degradation of these drugs in urine, human and rabbit serums was investigated. The slower degradation of carbisocaine was explained on the basis of steric hindrance.
摘要
描述了一种用于同时测定苯氨基甲酸酯类麻醉药庚卡因和卡比卡因及其代谢物的高效液相色谱法。使用该方法研究了这些药物在尿液、人和兔血清中的体外降解情况。基于空间位阻解释了卡比卡因降解较慢的原因。
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