Fried G
Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
Acta Physiol Scand. 1995 May;154(1):1-15. doi: 10.1111/j.1748-1716.1995.tb09880.x.
Neurotransmitter release from transmitter storage vesicles is a regulated signalling event that has properties in common with other secretory systems. Biochemical characterization of mammalian synaptic vesicle proteins has recently converged with studies of protein traffic in non-neuronal cells and the genetic dissection of the yeast secretory pathway to give us a considerable amount of new data. Many new synaptic vesicle proteins have been characterized together with plasma membrane proteins with which they interact, and it appears that many of the participating components may be part of a general machinery for secretion. The new results significantly improve our understanding of the molecular mechanisms governing transmitter release. This review discusses the recent progress in terms of synaptic vesicle components and the proposed mechanisms for exocytosis.
神经递质从递质储存囊泡的释放是一个受调控的信号事件，具有与其他分泌系统相同的特性。哺乳动物突触囊泡蛋白的生化特性研究最近与非神经元细胞中的蛋白质运输研究以及酵母分泌途径的基因剖析相结合，为我们提供了大量新数据。许多新的突触囊泡蛋白以及它们与之相互作用的质膜蛋白已得到表征，并且似乎许多参与成分可能是分泌通用机制的一部分。这些新结果显著提高了我们对控制递质释放的分子机制的理解。本综述讨论了在突触囊泡成分和提出的胞吐作用机制方面的最新进展。
