Linden M, Borchelt M, Barnow S, Geiselmann B
Department of Psychiatry, Free University of Berlin, Germany.
Acta Psychiatr Scand. 1995 Aug;92(2):150-4. doi: 10.1111/j.1600-0447.1995.tb09559.x.
The Hamilton Depression Rating Scale (HDRS) is world-wide the most important observer rating scale for depression. Many items of this scale refer to somatic symptoms of depression which cast doubt on the validity of HDRS scores in the presence of somatic comorbidity as, for example, in elderly patients. The present study, therefore, was planned to investigate the validity of the HDRS in cases in which the patient is suffering from a depressive illness together with somatic illnesses. The study population (n = 516) is a representative sample of citizens aged 70 years and older in West Berlin. They were assessed independently by internists and psychiatrists. Each positive item of the HDRS scale was then rated by the internists as to what degree it reflects somatic morbidity. Results show that multimorbidity interferes with the validity of the HDRS. There were 8 items for which more than half of all positive scores as rated by psychiatrists were seen by the internists as being possibly related to somatic disorders. Patients with corrections in the HDRS score showed a somewhat increased rate of medicines and cardiovascular diagnoses. There was less ambiguity for items with greater severity.
汉密尔顿抑郁量表(HDRS)是全球最重要的抑郁症观察评定量表。该量表的许多项目涉及抑郁症的躯体症状,这使得在存在躯体合并症的情况下,如老年患者,HDRS评分的有效性受到质疑。因此,本研究旨在调查HDRS在患者同时患有抑郁症和躯体疾病的情况下的有效性。研究人群(n = 516)是西柏林70岁及以上公民的代表性样本。他们由内科医生和精神科医生独立评估。然后,内科医生对HDRS量表的每个阳性项目在多大程度上反映躯体疾病进行评分。结果表明,多种疾病并存会干扰HDRS的有效性。有8个项目,内科医生认为精神科医生评定的所有阳性评分中超过一半可能与躯体疾病有关。HDRS评分有修正的患者用药和心血管疾病诊断率略有增加。严重程度较高的项目歧义较少。