Addington D, Addington J, Atkinson M
Department of Psychiatry, Foothills Hospital, Calgary, Alberta, Canada.
Schizophr Res. 1996 May;19(2-3):205-12. doi: 10.1016/0920-9964(95)00070-4.
This study compared two measures of depression in a population with schizophrenia. Inpatients (n = 112) with schizophrenia, were assessed on the Hamilton (HDRS), and Calgary (CDSS) depression scales and the Positive and Negative Syndrome Scale (PANSS). Eighty-nine were reassessed 3 months later. A principal components factor analysis was applied to each depression scale. The relationship between measures of depression and positive and negative symptoms was explored using correlation, factor and regression analyses. There were no significant correlations between the total CDSS and positive or negative symptoms at either time. In contrast, the HDRS total score was correlated with both positive and negative syndromes at time 2. Moreover, a number of HDRS factors correlated significantly with the PANSS positive scale at both times and with the negative subscale score at time 2. Multiple regression analysis showed that the HDRS accounted for more of the variance in positive and negative symptoms scores than did the CDSS. The CDSS has fewer factors and less overlap with positive and negative symptoms than the HDRS. This suggests that it is a more specific measure of level of depression than the HDRS for individuals with schizophrenia.
本研究比较了精神分裂症患者群体中两种抑郁测量方法。对112名精神分裂症住院患者进行了汉密尔顿抑郁量表（HDRS）、卡尔加里抑郁量表（CDSS）以及阳性和阴性症状量表（PANSS）评估。89名患者在3个月后接受了重新评估。对每个抑郁量表进行了主成分因子分析。使用相关性分析、因子分析和回归分析探讨了抑郁测量与阳性和阴性症状之间的关系。在两个时间点，CDSS总分与阳性或阴性症状之间均无显著相关性。相比之下，HDRS总分在时间点2与阳性和阴性综合征均相关。此外，多个HDRS因子在两个时间点均与PANSS阳性量表显著相关，在时间点2与阴性分量表得分显著相关。多元回归分析表明，与CDSS相比，HDRS在阳性和阴性症状得分的方差解释方面占比更大。与HDRS相比，CDSS的因子更少，与阳性和阴性症状的重叠更少。这表明，对于精神分裂症患者，CDSS是一种比HDRS更具特异性的抑郁水平测量方法。
