Aslan V, Thamsborg S M, Jørgensen R J, Basse A
Department of Clinical Studies, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
Acta Vet Scand. 1995;36(1):65-77. doi: 10.1186/BF03547703.
Ruminal acidosis was induced in twenty-one 10-month-old West African Dwarf Goats by feeding a suspension of 80 g wheat flour per kg bodyweight (day 0) through a stomach tube. Ruminal and systemic acidosis was diagnosed on day 1 in all goats. Clinical signs included loss of rumination and appetite, trembling, and watery diarrhoea. The detection of acidic faeces during the first 24h was considered of diagnostic importance. Subgroups were treated orally on days 1, 2, and 3 either with 1 g of sodium bicarbonate per kg bodyweight, with 1 g of baking yeast per kg, or with a combination of these treatments at 0.5 g of each per kg. A fourth group served as untreated controls. Peroral bicarbonate neutralization was highly effective in the treatment of rumen acidosis, whereas the use of yeast was found ineffective. The combined treatment had a moderate effect probably due to the bicarbonate. Three fatal cases (60%) occurred in the untreated group compared with none in the bicarbonate group, and 2 in each of the remaining groups. This corresponded to 33% of the yeast treated group and 40% of the combined treated group. Details were given on post mortem examinations performed on all survivors on day 11. Lesions included subacute rumenitis and abomasal ulcers. No lesions were found in 3 of the bicarbonate treated goats and in 2 of the animals receiving combined treatment.
通过胃管给21只10月龄的西非矮山羊投喂每千克体重80克小麦粉的悬浮液（第0天），诱导瘤胃酸中毒。所有山羊在第1天被诊断为瘤胃和全身酸中毒。临床症状包括反刍和食欲丧失、颤抖及水样腹泻。在最初24小时内检测到酸性粪便被认为具有诊断意义。在第1、2和3天，各亚组分别口服每千克体重1克碳酸氢钠、每千克体重1克烘焙酵母或两种治疗方法各0.5克的组合。第四组作为未治疗的对照组。口服碳酸氢钠中和对瘤胃酸中毒的治疗非常有效，而发现使用酵母无效。联合治疗可能由于碳酸氢钠而有中度效果。未治疗组发生3例死亡病例（60%），而碳酸氢钠组无死亡病例，其余各组各有2例死亡。这相当于酵母治疗组的33%和联合治疗组的40%。给出了在第11天对所有存活山羊进行尸检的详细情况。病变包括亚急性瘤胃炎和皱胃溃疡。在3只接受碳酸氢钠治疗的山羊和2只接受联合治疗的动物中未发现病变。
