Mills K C
Mid-America Poison Control Center, University of Kansas Medical Center, Kansas City, USA.
Am Fam Physician. 1995 Oct;52(5):1475-82.
Serotonin syndrome is a potentially life-threatening complication of psychopharmacologic drug therapy. The syndrome is produced most often by the concurrent use of two or more drugs that increase brainstem serotonin activity and is often unrecognized because of the varied and nonspecific nature of its symptomatology. Serotonin syndrome is characterized by alterations in cognition, behavior, autonomic nervous system function and neuromuscular activity. Patients with serotonin syndrome usually respond to discontinuation of drug therapy and supportive care alone, but they may require treatment with a specific antiserotonergic drug such as cyproheptadine, methysergide and/or propranolol.
血清素综合征是精神药物治疗中一种潜在的危及生命的并发症。该综合征最常由同时使用两种或更多种增加脑干血清素活性的药物引起，并且由于其症状的多样性和非特异性，常常未被识别。血清素综合征的特征是认知、行为、自主神经系统功能和神经肌肉活动的改变。血清素综合征患者通常仅通过停用药物治疗和支持性护理即可缓解，但可能需要使用特定的抗血清素能药物进行治疗，如赛庚啶、甲基麦角新碱和/或普萘洛尔。
