Coburn S P, Thampy K G, Lane H W, Conn P S, Ziegler P J, Costill D L, Mahuren J D, Fink W J, Pearson D R, Schaltenbrand W E
Biochemistry Department, Fort Wayne State Developmental Center, IN, USA.
Am J Clin Nutr. 1995 Nov;62(5):979-83. doi: 10.1093/ajcn/62.5.979.
Vitamin B-6 metabolism in 10 volunteers during 21 d of total fasting was compared with results from 10 men consuming a diet low only in vitamin B-6 (1.76 mumol/d) and with men consuming a normal diet during bed rest. At the end of the fast mean plasma concentrations of vitamin B-6 metabolites and urinary excretion of 4-pyridoxic acid tended to be higher in the fasting subjects than in the low-vitamin B-6 group. The fasting subjects lost approximately 10% of their total vitamin B-6 pool and approximately 13% of their body weight. The low-vitamin B-6 group lost only approximately 4% of their vitamin B-6 pool. Compared with baseline, urinary excretion of pyridoxic acid was significantly increased during 17 wk of bed rest. There was no increase in pyridoxic acid excretion during a second 15-d bed rest study. These data suggest the possibility of complex interactions between diet and muscle metabolism that may influence indexes that are frequently used to assess vitamin B-6 status.
对10名志愿者在21天完全禁食期间的维生素B-6代谢情况，与10名仅摄入低维生素B-6饮食（1.76微摩尔/天）的男性以及卧床休息期间摄入正常饮食的男性的结果进行了比较。禁食结束时，禁食受试者的维生素B-6代谢物平均血浆浓度和4-吡哆酸的尿排泄量往往高于低维生素B-6组。禁食受试者的总维生素B-6储备损失了约10%，体重减轻了约13%。低维生素B-6组仅损失了约4%的维生素B-6储备。与基线相比，卧床休息17周期间吡哆酸的尿排泄量显著增加。在第二项为期15天的卧床休息研究中，吡哆酸排泄量没有增加。这些数据表明饮食与肌肉代谢之间可能存在复杂的相互作用，这可能会影响常用于评估维生素B-6状态的指标。
