Moulton L H, Wolff M C, Brenneman G, Santosham M
Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA.
Am J Epidemiol. 1995 Nov 1;142(9):1000-6. doi: 10.1093/oxfordjournals.aje.a117730.
Evaluation of vaccine field effectiveness may be performed by combining surveillance data on incident cases with an immunization coverage survey. Although many methods have been used for the analysis of studies of similar design, they are not always desirable or optimal. The authors discuss these approaches and propose use of a case-cohort analysis for such a study design when appropriate. The case-cohort analytic approach is illustrated with data from studies of a vaccine for Haemophilus influenzae type b (Hib) disease in children living on a southwestern Native American reservation during 1988-1993.
通过将发病病例的监测数据与免疫接种覆盖率调查相结合，可以对疫苗的现场有效性进行评估。尽管许多方法已用于类似设计研究的分析，但它们并不总是理想或最佳的。作者讨论了这些方法，并建议在适当情况下对这种研究设计采用病例队列分析。本文以1988年至1993年期间在西南部美洲原住民保留地生活的儿童中进行的b型流感嗜血杆菌（Hib）疾病疫苗研究数据为例，说明了病例队列分析方法。
