Pollock C, Gyory A Z, Hawkins T, Ross M, Ibels L
Department of Medicine, Sydney University and Renal Medicine, Royal North Shore Hospital, St. Leonards, Australia.
Am J Nephrol. 1995;15(4):277-82. doi: 10.1159/000168849.
125I-iothalamate and true endogenous creatinine clearances, measured over two short collections periods of 1 and 2 h, were compared simultaneously in 70 patients with a variety of renal diseases and a wide range of renal function. Reproducibility of the iothalamate clearance was 18.5% and that of the creatinine clearance 12.2%. The slope of the regression was not significantly different from 1 (95% confidence interval, CI, 0.964-1.155) for the whole group, nor in any subgroup chosen. The intercept at 12.6 ml/min (CI = 5.0-20.2) indicates that there is some creatinine secretion, but this was constant at all levels of GFR. It is concluded that although the clearance of true creatinine obtained during short collection periods consistently overestimates GFR by a constant proportion, it is a reproducible and accurate measure of GFR suitable for use in the clinical setting.
在70例患有各种肾脏疾病且肾功能范围广泛的患者中，同时比较了在两个1小时和2小时的短收集期内测得的125I-碘肽酸盐清除率和真正的内生肌酐清除率。碘肽酸盐清除率的重复性为18.5%，肌酐清除率的重复性为12.2%。整个组以及所选的任何亚组中，回归斜率与1无显著差异（95%置信区间，CI，0.964 - 1.155）。12.6 ml/min处的截距（CI = 5.0 - 20.2）表明存在一定的肌酐分泌，但在所有肾小球滤过率（GFR）水平下均保持恒定。结论是，尽管在短收集期内获得的真正肌酐清除率始终以恒定比例高估GFR，但它是一种可重复且准确的GFR测量方法，适用于临床环境。
