Tessitore N, Lo Schiavo C, Corgnati A, Previato G, Valvo E, Lupo A, Chiaramonte S, Messa P, D'Angelo A, Zatti M, Maschio G
Nephron. 1979;24(1):41-5. doi: 10.1159/000181681.
In 196 adult patients with chronic renal disease or primary hypertension, the evaluation of glomerular filtration rate (GFR) by means of creatinine clearance, 'predicted' creatinine clearance and [125I]-iothalamate clearance was performed. Iothalamate clearance was evaluated after subcutaneous injection of the substance . In patients with normal or upper borderline plasma creatinine values, the iothalamate clearance ranged from 44 to 117 ml/min/1.73 m2 and the overestimation of GFR from creatinine clearance was negligible. In patients with mild or advanced renal failure, the overestimation of GFR from creatinine clearance increased up to 18 and 32%, respectively. The clinical usefulness of iothalamate clearance is evident especially in patients with mild renal failure, in whom an accurate evaluation of GFR is often important for a correct dietary and therapeutic approach.
对196例慢性肾病或原发性高血压患者，采用肌酐清除率、“预测”肌酐清除率及[125I] - 碘肽酸盐清除率评估肾小球滤过率（GFR）。皮下注射该物质后评估碘肽酸盐清除率。血浆肌酐值正常或处于临界上限的患者，碘肽酸盐清除率范围为44至117 ml/min/1.73 m2，肌酐清除率对GFR的高估可忽略不计。轻度或重度肾衰竭患者中，肌酐清除率对GFR的高估分别增至18%和32%。碘肽酸盐清除率的临床实用性尤其在轻度肾衰竭患者中很明显，对这类患者而言，准确评估GFR对正确的饮食和治疗方法通常很重要。
