Jayasena S D, Woolfson R G, Griffiths M H, Neild G H
Division of Renal Medicine, University College London Medical School, Middlesex Hospital, UK.
Am J Nephrol. 1995;15(4):361-3. doi: 10.1159/000168865.
We describe a patient with nephrotic syndrome due to focal-segmental glomerulosclerosis, occurring 3 years after thymectomy and myasthenia gravis. Nine other cases of nephrotic syndrome associated with thymoma and myasthenia gravis reported in the literature are reviewed. The nephrotic syndrome may be due to T cell dysfunction associated with thymoma; however, animal models suggest that genetic factors may also be involved.
我们描述了一名因局灶节段性肾小球硬化症导致肾病综合征的患者，该病在胸腺切除术后3年及重症肌无力发生后出现。本文回顾了文献中报道的其他9例与胸腺瘤和重症肌无力相关的肾病综合征病例。肾病综合征可能归因于与胸腺瘤相关的T细胞功能障碍；然而，动物模型表明遗传因素可能也与之有关。
