Busam K J, Berwick M, Blessing K, Fandrey K, Kang S, Karaoli T, Fine J, Cochran A J, White W L, Rivers J
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Am J Pathol. 1995 Oct;147(4):1049-56.
Tumor vascularity has been proposed as a prognostic indicator for a number of solid tumors. Although a correlation between microvessel number and metastatic behavior has also been suggested for cutaneous melanoma, the small number of cases studied to date allows one to draw only preliminary conclusions. In this study, we have assessed tumor vascularity in cutaneous melanoma by comparing 60 cases of metastasizing and non-metastasizing tumors matched for tumor thickness, age, sex, and anatomic site. Ulex europaeus agglutinin I appeared to be the most suitable vascular marker for this study. Our results indicate that there was no statistically significant difference between the two groups with regard to tumor vascularity. Even after identifying 15 cases of thin ( < 1.0 mm thick) melanoma, there was no significant difference in the number of microvessels between metastasizing and non-metastasizing tumors. Comparison of patterns of vascular microarchitecture also failed to discriminate between the two groups. Thus, our results indicate that tumor vascularity may not be an independent prognostic factor for cutaneous melanoma.
肿瘤血管生成已被认为是多种实体瘤的预后指标。虽然也有人提出皮肤黑色素瘤的微血管数量与转移行为之间存在相关性，但迄今为止所研究的病例数量较少，只能得出初步结论。在本研究中，我们通过比较60例肿瘤厚度、年龄、性别和解剖部位相匹配的转移性和非转移性皮肤黑色素瘤病例，评估了肿瘤血管生成情况。欧洲荆豆凝集素I似乎是本研究中最合适的血管标志物。我们的结果表明，两组之间在肿瘤血管生成方面没有统计学上的显著差异。即使在识别出15例薄型（厚度<1.0 mm）黑色素瘤后，转移性和非转移性肿瘤之间的微血管数量也没有显著差异。血管微结构模式的比较也未能区分这两组。因此，我们的结果表明，肿瘤血管生成可能不是皮肤黑色素瘤的独立预后因素。
