Barney C C, Folkerts M M
Department of Biology, Hope College, Holland, Michigan 49423, USA.
Am J Physiol. 1995 Sep;269(3 Pt 2):R557-64. doi: 10.1152/ajpregu.1995.269.3.R557.
Male Sprague-Dawley rats were used to study the possible role of hyperthermia in the thirst associated with thermal dehydration. Rats were exposed to 40 degrees C for 4 h and then allowed access to water at different times after they were transferred to 25 degrees C. Delaying the time prior to allowing the rats to drink did not significantly alter either water intake or percent rehydration even though core temperature decreased during the first 1.5 h after removal from the heat. Exposing thermally dehydrated rats to 5 degrees C for 30 min prior to allowing them access to water also failed to significantly affect water intake or percent rehydration. Thermally dehydrated rats allowed to drink while remaining in the heat did not show a significant increase in water intake during the first hour or percent rehydration over rats drinking at 25 degrees C. Nondehydrated rats did show significant increases in water intake and percent rehydration when allowed to drink in the heat. Hyperthermia does not play a role in drinking in thermally dehydrated rats but can stimulate drinking in water-replete rats.
采用雄性斯普拉格-道利大鼠来研究体温过高在与热脱水相关的口渴现象中可能起到的作用。将大鼠置于40摄氏度环境中4小时，然后在转移至25摄氏度环境后的不同时间点让它们饮水。延迟让大鼠饮水的时间，即便在从高温环境转移后的最初1.5小时内核心体温有所下降，也不会显著改变水摄入量或补液百分比。在让热脱水大鼠饮水前，先将其置于5摄氏度环境中30分钟，同样未能显著影响水摄入量或补液百分比。热脱水大鼠在仍处于高温环境时饮水，并不能在最初一小时内使其水摄入量或补液百分比相较于在25摄氏度环境中饮水的大鼠有显著增加。未脱水的大鼠在高温环境中饮水时，水摄入量和补液百分比确实有显著增加。体温过高在热脱水大鼠的饮水行为中不起作用，但能刺激水分充足的大鼠饮水。
