人类恶性疾病中的免疫活性细胞。II. 一例非霍奇金淋巴瘤的临床与免疫学关联
Immunocompetent cells in malignant disease in man. II. Clinical and immunologic correlates in a case of non-Hodgkin's lymphoma.
作者信息
Algom D, Rapp E, Hamdy H, Keaney M A, Hirte W, Klaassen D J, Richter M
出版信息
Can Med Assoc J. 1978 Jan 21;118(2):168-71.
The immunocompetence of the circulating lymphocytes of a patient with non-Hodgkin's lymphoma was evaluated before, during and after treatment. The immunologic features investigated were (a) the degree of blastogenic transformation induced by phytomitogens (phytohemagglutinin-M, concanavalin A and pokeweed mitogen); (b) the formation of E, EA and EAC rosettes; and (c) antibody-dependent, cell-mediated cytotoxicity. Prior to treatment the subnormal in vitro responsiveness of the cells and the very low concentrations of circulating immunoglobulins suggested immunoincompetence. A gradual shift towards normal in vitro values was observed during treatment, which corresponded to the clinical improvement in the patient's condition.
对一名非霍奇金淋巴瘤患者治疗前、治疗期间及治疗后的循环淋巴细胞免疫能力进行了评估。所研究的免疫学特征包括：(a) 植物凝集素（植物血凝素-M、刀豆球蛋白A和商陆有丝分裂原）诱导的母细胞转化程度；(b) E、EA和EAC玫瑰花结的形成；以及(c) 抗体依赖性细胞介导的细胞毒性。治疗前，细胞体外反应性低于正常水平且循环免疫球蛋白浓度极低，提示免疫功能不全。治疗期间观察到体外值逐渐向正常转变，这与患者病情的临床改善相一致。
Zotero 插件