Ueda W, Kataoka Y, Takimoto E, Tomoda M K, Aono J, Sagara Y, Manabe M
Department of Anesthesiology, Kochi Medical School, Japan.
Anesth Analg. 1995 Oct;81(4):703-5. doi: 10.1097/00000539-199510000-00008.
We investigated the hypothesis that ephedrine-induced increases in blood pressure accelerate the regression of epidural block. In patients undergoing minor gynecologic surgery, we performed lumbar epidural blockade using 2% lidocaine containing 1:200,000 epinephrine to which was added 0.1 mg of fentanyl. Eighty minutes after the epidural injection, we started an ephedrine infusion to increase the systolic blood pressure by 20% in 10 min and maintained the value for the following 20 min. Then we compared the proximal extent of sensory analgesia at 80 min with that at 140 min. Ephedrine significantly (P = 0.001) hastened the regression of sensory analgesia. We conclude that an ephedrine-induced blood pressure increase accelerates regression of epidural blockade.
麻黄碱引起的血压升高会加速硬膜外阻滞的消退。在接受小型妇科手术的患者中，我们使用含有1:200,000肾上腺素的2%利多卡因进行腰段硬膜外阻滞，并添加了0.1毫克芬太尼。硬膜外注射80分钟后，我们开始输注麻黄碱，在10分钟内将收缩压提高20%，并在接下来的20分钟内维持该值。然后我们比较了80分钟时与140分钟时感觉镇痛的近端范围。麻黄碱显著（P = 0.001）加速了感觉镇痛的消退。我们得出结论，麻黄碱引起的血压升高会加速硬膜外阻滞的消退。
