Vaxman F, Kolbe R, Stricher F, Boullenois J N, Volkmar P, Gros D, Grenier J F
Service de Chirurgie Digestive et Générale, Hôpitaux Universitaires de Strasbourg.
Ann Chir. 1995;49(5):411-6.
The aim of this prospective and randomized study, was to demonstrate the benefit by using fibrin glue after axillary lymph node dissection. From January 1990 to January 1991, forty females were randomized before surgery for breast cancer: 20 patients of the group A underwent additional application of fibrin glue (5 ml containing 500 IU of thrombin) by spray only in the area of axillary dissection, while the 20 patients of group B acted as the control group. The two groups were compared for age, number of nodes removed and involved, drainage volume and duration and complications. Student's t test, Mann and Whitney non parametric test and chi 2 were used when appropriate for statistical analysis. The two groups were well balanced for age, number of nodes removed and involved, staging and histologic findings. The average volume of lymphorrhoea in the lymph node dissection area was greater after use of fibrin glue (410.4 ml) than in controls (275.5 ml, p = 0.016). No difference was noted between the two groups for the volume of drainage of the mastectomy or lumpectomy site or, for the total volume of drainage. Drainage durations as well as hospital stay were similar. Six complications occurred in group A, and one in group B (p = 0.037).(ABSTRACT TRUNCATED AT 250 WORDS)
这项前瞻性随机研究的目的是证明在腋窝淋巴结清扫术后使用纤维蛋白胶的益处。从1990年1月至1991年1月，40名乳腺癌女性患者在手术前被随机分组：A组的20名患者仅在腋窝清扫区域通过喷雾额外应用纤维蛋白胶（5毫升含500国际单位凝血酶），而B组的20名患者作为对照组。比较两组患者的年龄、切除及受累淋巴结数量、引流量及持续时间和并发症情况。在适当情况下使用学生t检验、曼恩和惠特尼非参数检验以及卡方检验进行统计分析。两组在年龄、切除及受累淋巴结数量、分期和组织学结果方面平衡良好。使用纤维蛋白胶后，腋窝淋巴结清扫区域的平均淋巴漏量（410.4毫升）高于对照组（275.5毫升，p = 0.016）。两组在乳房切除术或肿块切除术部位的引流量或总引流量方面无差异。引流持续时间及住院时间相似。A组发生6例并发症，B组发生1例（p = 0.037）。（摘要截断于250字）
