Medl M, Mayerhofer K, Peters-Engl C, Mahrhofer P, Huber S, Buxbaum P, Sevelda P, Leodolter S
Department of Gynecology and Obstetrics, Lainz Hospital, Vienna, Austria.
Anticancer Res. 1995 Nov-Dec;15(6B):2843-5.
Experimental studies point out that a reduction of lymph flow can be obtained by the local application of fibrin glue following axillary lymphadenectomy in the surgical treatment of breast cancer. In a prospective study the influence of human fibrin glue on postoperative axillary lymph secretion and the period of drainage of the wound cavity were evaluated. In 40 patients, 5 ml of fibrin glue (Tissucol) was applied to the wound cavity by the use of a spray applicator (Tissumat) immediately after axillary dissection of the lymph nodes. For drainage of the wound area Redon suction-drains were used. The daily amount of postoperative lymph secretion was measured and drains were removed at a lymph secretion of less than 20 ml. 40 patients who underwent surgery and axillary lymphadenectomy without subsequent application of fibrin glue sourced as control group. No significant difference concerning the total amount of lymph secretion, the mean period of drainage or the incidence of lymphatic cysts was observed. In our study, the expected occlusion of the wound cavity by the application of fibrin glue after axillary lymphadenectomy did not lead to any advantage when compared with the control group.
实验研究指出，在乳腺癌手术治疗中，腋窝淋巴结清扫术后局部应用纤维蛋白胶可减少淋巴液流动。在一项前瞻性研究中，评估了人纤维蛋白胶对术后腋窝淋巴分泌及伤口腔引流时间的影响。40例患者在腋窝淋巴结清扫术后立即使用喷雾器（Tissumat）将5毫升纤维蛋白胶（Tissucol）喷于伤口腔。伤口区域用雷顿负压引流管引流。测量术后每日淋巴分泌量，当淋巴分泌量少于20毫升时拔除引流管。40例行手术及腋窝淋巴结清扫术但未应用纤维蛋白胶的患者作为对照组。在淋巴分泌总量、平均引流时间或淋巴管囊肿发生率方面未观察到显著差异。在我们的研究中，与对照组相比，腋窝淋巴结清扫术后应用纤维蛋白胶预期的伤口腔闭塞并未带来任何优势。
