Ng S C
Subang Jaya Medical Centre, Selangor, Malaysia.
Ann Acad Med Singap. 1995 May;24(3):465-6.
Drug-induced agranulocytosis is a potentially fatal complication despite advances in supportive care. A patient with carbimazole-induced agranulocytosis associated with marked depletion of granulocytic precursors in the marrow was treated with granulocyte-macrophage colony stimulating factor (GM-CSF) at a dose of 5 micrograms/kg subcutaneously daily for one week. The absolute neutrophil count rose above 1 x 10(9)/L after one week of GM-CSF therapy. The GM-CSF probably expedited the recovery of the neutrophil count. Further studies are warranted to delineate the role of GM-CSF in the treatment of drug-induced agranulocytosis.
尽管在支持性护理方面取得了进展，但药物性粒细胞缺乏症仍是一种潜在的致命并发症。一名因卡比马唑导致粒细胞缺乏症且伴有骨髓中粒细胞前体明显减少的患者，接受了粒细胞-巨噬细胞集落刺激因子（GM-CSF）治疗，剂量为每日皮下注射5微克/千克，持续一周。GM-CSF治疗一周后，绝对中性粒细胞计数升至1×10⁹/L以上。GM-CSF可能加速了中性粒细胞计数的恢复。有必要进行进一步研究以明确GM-CSF在药物性粒细胞缺乏症治疗中的作用。
