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本文引用的文献

1
Liposomes as in-vivo carriers for citicoline: effects on rat cerebral post-ischaemic reperfusion.脂质体作为胞磷胆碱的体内载体：对大鼠脑缺血后再灌注的影响。
J Pharm Pharmacol. 1994 Dec;46(12):974-81. doi: 10.1111/j.2042-7158.1994.tb03252.x.
2
Legionnaires' disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytes.军团菌病细菌（嗜肺军团菌）在人类单核细胞内进行细胞内增殖。
J Clin Invest. 1980 Sep;66(3):441-50. doi: 10.1172/JCI109874.
3
Antibiotic entry into human polymorphonuclear leukocytes.抗生素进入人多形核白细胞的过程。
Antimicrob Agents Chemother. 1982 Mar;21(3):373-80. doi: 10.1128/AAC.21.3.373.
4
Clinical pharmacokinetics of cerebrospinal fluid.脑脊液的临床药代动力学
Clin Pharmacokinet. 1982 Jul-Aug;7(4):312-35. doi: 10.2165/00003088-198207040-00003.
5
Liposomes in antimicrobial chemotherapy.抗菌化疗中的脂质体
J Antimicrob Chemother. 1983 Dec;12(6):532-4. doi: 10.1093/jac/12.6.532.
6
Intracellular penetration and antimicrobial activity of antibiotics.抗生素的细胞内渗透及抗菌活性
J Antimicrob Chemother. 1983 Oct;12 Suppl C:13-20. doi: 10.1093/jac/12.suppl_c.13.
7
Radiopaque liposomes: effect of formulation conditions on encapsulation efficiency.不透射线脂质体：制剂条件对包封率的影响
J Pharm Sci. 1984 Dec;73(12):1751-5. doi: 10.1002/jps.2600731223.
8
Liposome-encapsulated cephalothin in the treatment of experimental murine salmonellosis.脂质体包裹的头孢噻吩治疗实验性小鼠沙门氏菌病
J Reticuloendothel Soc. 1983 Oct;34(4):279-87.
9
Intraphagocytic killing of Salmonella typhimurium by liposome-encapsulated cephalothin.脂质体包裹头孢噻吩对鼠伤寒沙门氏菌的吞噬细胞内杀伤作用
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10
Oral absorption of griseofulvin in dogs: increased absorption via solid dispersion in polyethylene glycol 6000.灰黄霉素在犬体内的口服吸收：通过在聚乙二醇6000中形成固体分散体提高吸收效果。
J Pharm Sci. 1970 Jul;59(7):937-42. doi: 10.1002/jps.2600590703.

载氧氟沙星脂质体在人滑膜成纤维细胞内的积累。 （注：原文中多了一个of，正确表述应该是Intracellular accumulation of ofloxacin-loaded liposomes in human synovial fibroblasts. ）

Intracellular accumulation of ofloxacin-loaded liposomes in human synovial fibroblasts.

作者信息

Fresta M, Spadaro A, Cerniglia G, Ropero I M, Puglisi G, Furneri P M

机构信息

Institute of Pharmaceutical and Toxicological Chemistry, Catania, Italy.

出版信息

Antimicrob Agents Chemother. 1995 Jun;39(6):1372-5. doi: 10.1128/AAC.39.6.1372.

DOI:10.1128/AAC.39.6.1372
PMID:7574534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162745/
Abstract

In order to incorporate ofloxacin within liposomes, the reverse-phase evaporation technique was carried out. The liposome lipid matrix consisted of dipalmitoylphosphatidylcholine-cholesterol-dihexadecylphosphate (4: 3:4 molar ratio). The liposome formulation presented a mean size of 185 +/- 31 nm and had an encapsulation capacity of 5.3 microliters/mumol. The liposome formulation was able to deliver ofloxacin into McCoy cells in a greater amount (2.6-fold) than the free drug, improving antibiotic accumulation.

摘要

为了将氧氟沙星包封于脂质体中，采用了逆相蒸发技术。脂质体脂质基质由二棕榈酰磷脂酰胆碱 - 胆固醇 - 二己基磷酸酯（摩尔比4:3:4）组成。该脂质体制剂的平均粒径为185±31nm，包封容量为5.3微升/微摩尔。与游离药物相比，该脂质体制剂能够将更多量的氧氟沙星递送至McCoy细胞中（2.6倍），提高了抗生素的蓄积。