载氧氟沙星脂质体在人滑膜成纤维细胞内的积累。 （注：原文中多了一个of，正确表述应该是Intracellular accumulation of ofloxacin-loaded liposomes in human synovial fibroblasts. ）
Intracellular accumulation of ofloxacin-loaded liposomes in human synovial fibroblasts.
作者信息
Fresta M, Spadaro A, Cerniglia G, Ropero I M, Puglisi G, Furneri P M
机构信息
Institute of Pharmaceutical and Toxicological Chemistry, Catania, Italy.
出版信息
Antimicrob Agents Chemother. 1995 Jun;39(6):1372-5. doi: 10.1128/AAC.39.6.1372.
Abstract
In order to incorporate ofloxacin within liposomes, the reverse-phase evaporation technique was carried out. The liposome lipid matrix consisted of dipalmitoylphosphatidylcholine-cholesterol-dihexadecylphosphate (4: 3:4 molar ratio). The liposome formulation presented a mean size of 185 +/- 31 nm and had an encapsulation capacity of 5.3 microliters/mumol. The liposome formulation was able to deliver ofloxacin into McCoy cells in a greater amount (2.6-fold) than the free drug, improving antibiotic accumulation.
摘要
为了将氧氟沙星包封于脂质体中，采用了逆相蒸发技术。脂质体脂质基质由二棕榈酰磷脂酰胆碱 - 胆固醇 - 二己基磷酸酯（摩尔比4:3:4）组成。该脂质体制剂的平均粒径为185±31nm，包封容量为5.3微升/微摩尔。与游离药物相比，该脂质体制剂能够将更多量的氧氟沙星递送至McCoy细胞中（2.6倍），提高了抗生素的蓄积。
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