Ebina T, Murata K
Division of Immunology, Miyagi Cancer Center.
Gan To Kagaku Ryoho. 1995 Sep;22(11):1626-8.
The effect of intratumoral administration of BRMs in Meth-A solid tumor has been analyzed in BALB/c mice. The effect of BRMs on in vitro invasion by murine RL male-1 leukemia cells was studied using Biocoat Matrigel Invasion Chamber (Becton Dickinson Labware). We determined the ability of tumor cells to penetrate matrigel-coated filters in the presence or absence of BRM. PSK or OK-432 inhibited tumor cell invasion of matrigel-coated filters in a dose-dependent manner. PSK, OK-432 and Cepharanthin inhibited invasion of murine Colon 26 carcinoma cells and human A 375. S2 melanoma cells. On the other hand, polysaccharide preparations without protein, Lentinan or Sonifilan inhibited neither tumor growth nor tumor cell invasion.
已在BALB/c小鼠中分析了瘤内给予生物反应调节剂（BRMs）对Meth-A实体瘤的影响。使用BioCoat Matrigel侵袭小室（Becton Dickinson Labware）研究了BRMs对小鼠RL male-1白血病细胞体外侵袭的影响。我们测定了在有或无BRM的情况下肿瘤细胞穿透基质胶包被滤膜的能力。PSK或OK-432以剂量依赖方式抑制肿瘤细胞对基质胶包被滤膜的侵袭。PSK、OK-432和千金藤素抑制小鼠结肠26癌细胞和人A 375.S2黑色素瘤细胞的侵袭。另一方面，不含蛋白质的多糖制剂香菇多糖或裂褶菌多糖既不抑制肿瘤生长也不抑制肿瘤细胞侵袭。
