Sasaki F, Ishimura H, Takada N, Uchino J
First Department of Surgery, Hokkaido University, School of Medicine.
Gan To Kagaku Ryoho. 1995 Oct;22(12):1777-81.
In vitro MTT assay was applied for examining chemosensitivity with 50 thyroid cancers; 47 papillary cancers, 1 follicular cancer, 1 anaplastic cancers, and 1 medullary cancer. Anticancer drugs examined were 5-fluorouracil (5-FU), cisplatin (CDDP), adriamycin (ADM), etoposide (VP-16) and ifosfamide (IFO) (active type). Their efficacy was as follows: 5-FU 0%, CDDP 40.9%, ADM 0%, VP-16 5.3%, IFO 48.5%. Anaplastic cancer and medullary cancer showed no sensitivity to all tested drugs. We compared the chemosensitivity between cancer tissue and normal tissue. CDDP was more effective in cancer tissue than in normal tissue. Chemosensitivity of CDDP depended on the drug concentration but 5-FU did not. CDDP and IFO might be useful against human differentiated thyroid cancer.
采用体外MTT法检测50例甲状腺癌的化疗敏感性，其中包括47例乳头状癌、1例滤泡状癌、1例未分化癌和1例髓样癌。检测的抗癌药物有5-氟尿嘧啶（5-FU）、顺铂（CDDP）、阿霉素（ADM）、依托泊苷（VP-16）和异环磷酰胺（IFO）（活性型）。它们的疗效如下：5-FU为0%，CDDP为40.9%，ADM为0%，VP-16为5.3%，IFO为48.5%。未分化癌和髓样癌对所有测试药物均无敏感性。我们比较了癌组织和正常组织之间的化疗敏感性。CDDP在癌组织中的效果比在正常组织中更显著。CDDP的化疗敏感性取决于药物浓度，但5-FU并非如此。CDDP和IFO可能对人类分化型甲状腺癌有效。
