Kondo K, Akiyama S, Nonami T, Kasai Y, Hibi K, Ito K, Takagi H
Dept. of Surgery II, Nagoya University School of Medicine.
Gan To Kagaku Ryoho. 1995 Oct;22(12):1839-42.
We report a case of double cancer of esophagus and stomach treated with 5-fluorouracil and consecutive low-dose cisplatin. The patient was a 58-year-old man with liver cirrhosis. Using upper gastrointestinal fiberscopy, a superficial depressed lesion (O-IIc) in the middle thoracic part of the esophagus and Borrmann 2 type lesion in the fundus of the stomach were also detected. Microscopic examination of the biopsy specimen revealed moderately differentiated squamous cell carcinoma and adenocarcinoma. But laparotomy could not be done due to impaired liver function (KICG 0.051, ICGR15 45.2%). The patient was treated for 28 days with continuous 24 hour infusion 5-FU, 250 mg/body/day plus low dose CD-DP, 10 mg/body daily by bolus infusion d1-5, 8-12, 15-19, 22-26. One month after the chemotherapy, both the gastric cancer and the esophageal cancer were remarkably reduced (diagnosis: PR), and showed no malignancy in the histology. There was no change in the histological findings of the esophageal lesion at 31 months after the chemotherapy. This therapy is effective for patients with gastric cancer and esophageal cancer.
我们报告一例采用5-氟尿嘧啶和连续低剂量顺铂治疗的食管和胃癌双原发癌病例。患者为一名58岁的肝硬化男性。通过上消化道纤维内镜检查，还发现食管胸中段有一浅表凹陷性病变（O-IIc型），胃底有Borrmann 2型病变。活检标本的显微镜检查显示为中分化鳞状细胞癌和腺癌。但由于肝功能受损（KICG 0.051，ICGR15 45.2%），无法进行剖腹手术。患者接受了28天的治疗，持续24小时输注5-氟尿嘧啶，250mg/体/天，加低剂量顺铂，10mg/体，于第1 - 5天、8 - 12天、15 - 19天、22 - 26天通过静脉推注给药。化疗1个月后，胃癌和食管癌均显著缩小（诊断：PR），组织学检查未显示恶性。化疗后31个月，食管病变的组织学检查结果无变化。该疗法对胃癌和食管癌患者有效。
