Mizuno Y, Muraoka M, Aiso S, Munakata Y, Ono A, Tsuchiya M, Shimabukuro K, Ito M
Biochem Exp Biol. 1978;14(4):329-34.
We succeeded in the culture of the thymic epithelium which obtained from the patients with various autoimmune diseases aged from 20 to 65 years whose thymuses should have already been involuted with decreased thymic function. The mean percentage of active rosette-forming cells significantly increased after the incubation with thymic monolayer culture medium. These observations suggest that thymic epithelia in autoimmune diseases produce thymosin-like factor(s) in culture medium.
我们成功培养了从20至65岁患有各种自身免疫性疾病患者身上获取的胸腺上皮细胞，这些患者的胸腺本应已经萎缩且胸腺功能下降。在用胸腺单层培养基孵育后，活性玫瑰花结形成细胞的平均百分比显著增加。这些观察结果表明，自身免疫性疾病中的胸腺上皮细胞在培养基中产生胸腺素样因子。
