玻璃体内注射地塞米松对兔肺炎球菌性眼内炎的治疗效果。
Effect of intravitreal dexamethasone in treatment of pneumococcal endophthalmitis in rabbits.
作者信息
Park S S, Samiy N, Ruoff K, D'Amico D J, Baker A S
机构信息
Department of Ophthalmology, University of Texas, Southwestern Medical Center, Dallas, USA.
出版信息
Arch Ophthalmol. 1995 Oct;113(10):1324-9. doi: 10.1001/archopht.1995.01100100112040.
PURPOSE
To investigate whether corticosteroid therapy would decrease the inflammation and tissue damage associated with pneumococcal endophthalmitis.
METHODS
Albino rabbits were injected intravitreally with 1000 live organisms of Streptococcus pneumoniae and randomized after 24 hours to treatment with intravitreal vancomycin hydrochloride alone (n = 10), combination intravitreal vancomycin and intravitreal dexamethasone (n = 10), or no treatment (n = 10). After 2 weeks, the eyes were examined clinically and enucleated for histopathologic examination.
RESULTS
Eyes treated with vancomycin and dexamethasone had significantly less intraocular inflammation and more preservation of retinal tissue than untreated eyes or eyes treated with vancomycin alone (P < .05, Fisher's exact test). Untreated and vancomycin-treated eyes were indistinguishable on clinical and histologic examination. Marked anterior and posterior segment inflammation with total retinal necrosis was noted in eyes from both groups.
CONCLUSION
Intravitreal corticosteroid therapy may play an important role in minimizing the inflammation and tissue damage associated with pneumococcal endophthalmitis.
目的
研究皮质类固醇疗法是否会减轻与肺炎球菌性眼内炎相关的炎症和组织损伤。
方法
对白化兔玻璃体内注射1000个肺炎链球菌活菌体，24小时后随机分为三组，分别接受单纯玻璃体内注射盐酸万古霉素治疗（n = 10）、玻璃体内联合注射万古霉素和地塞米松治疗（n = 10）或不治疗（n = 10）。2周后，对眼睛进行临床检查，并摘除眼球进行组织病理学检查。
结果
与未治疗的眼睛或仅接受万古霉素治疗的眼睛相比，接受万古霉素和地塞米松治疗的眼睛眼内炎症明显减轻，视网膜组织保存得更多（P <.05，Fisher精确检验）。在临床和组织学检查中，未治疗的眼睛和接受万古霉素治疗的眼睛无法区分。两组眼睛均出现明显的前段和后段炎症以及全视网膜坏死。
结论
玻璃体内注射皮质类固醇疗法在减轻与肺炎球菌性眼内炎相关的炎症和组织损伤方面可能发挥重要作用。
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