• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The toxicity in vitro of beta-amyloid protein.

作者信息

Iversen L L, Mortishire-Smith R J, Pollack S J, Shearman M S

机构信息

Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, U.K.

出版信息

Biochem J. 1995 Oct 1;311 ( Pt 1)(Pt 1):1-16. doi: 10.1042/bj3110001.

DOI:10.1042/bj3110001
PMID:7575439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1136112/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e9/1136112/60b47b5ac669/biochemj00054-0023-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e9/1136112/27fbabeaf605/biochemj00054-0011-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e9/1136112/e0746c2e85c3/biochemj00054-0013-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e9/1136112/708da69811fb/biochemj00054-0014-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e9/1136112/fa6f8e51f711/biochemj00054-0016-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e9/1136112/60b47b5ac669/biochemj00054-0023-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e9/1136112/27fbabeaf605/biochemj00054-0011-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e9/1136112/e0746c2e85c3/biochemj00054-0013-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e9/1136112/708da69811fb/biochemj00054-0014-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e9/1136112/fa6f8e51f711/biochemj00054-0016-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e9/1136112/60b47b5ac669/biochemj00054-0023-a.jpg

相似文献

1
The toxicity in vitro of beta-amyloid protein.β-淀粉样蛋白的体外毒性
Biochem J. 1995 Oct 1;311 ( Pt 1)(Pt 1):1-16. doi: 10.1042/bj3110001.
2
beta-Amyloid protein induces platelet aggregation and supports platelet adhesion.β-淀粉样蛋白诱导血小板聚集并促进血小板黏附。
Biochem Biophys Res Commun. 1994 Dec 30;205(3):1829-35. doi: 10.1006/bbrc.1994.2883.
3
Untangling the pathophysiochemistry of beta-amyloid.解析β-淀粉样蛋白的病理生理化学机制
Nat Struct Biol. 1995 Nov;2(11):926-8. doi: 10.1038/nsb1195-926.
4
[Conformation and neurotoxicity: relationship between Alzheimer's disease and prion disease].[构象与神经毒性：阿尔茨海默病与朊病毒病之间的关系]
Seikagaku. 1998 Dec;70(12):1422-6.
5
[Molecular neurobiology of Alzheimer amyloid protein precursor].
Seikagaku. 1993 Sep;65(9):1149-59.
6
Development of retro-inverso peptides as anti-aggregation drugs for β-amyloid in Alzheimer's disease.反义肽作为阿尔茨海默病β-淀粉样蛋白聚集抑制剂的研发。
Peptides. 2010 Oct;31(10):1866-72. doi: 10.1016/j.peptides.2010.06.033. Epub 2010 Jul 13.
7
[Morphology and neurotoxicity of newly identified spherical beta-amyloid aggregates, 'amylospheroid', aiming at elucidation of the neurodegenerative cascades in Alzheimer's disease].[新发现的球形β-淀粉样蛋白聚集体“淀粉样球状体”的形态学与神经毒性，旨在阐明阿尔茨海默病中的神经退行性级联反应]
Seikagaku. 2004 Jul;76(7):631-9.
8
Amyloid peptides are toxic via a common oxidative mechanism.淀粉样肽通过一种常见的氧化机制产生毒性。
Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):1989-93. doi: 10.1073/pnas.92.6.1989.
9
Radical changes in beta-amyloid form and function.β-淀粉样蛋白的形式和功能发生了根本性变化。
Mol Chem Neuropathol. 1996 May-Aug;28(1-3):49-55. doi: 10.1007/BF02815204.
10
Light-controlled toxicity of engineered amyloid β-peptides.光控工程淀粉样 β 肽的毒性。
Chembiochem. 2012 Dec 21;13(18):2657-60. doi: 10.1002/cbic.201200605. Epub 2012 Nov 19.

引用本文的文献

1
A Novel Model of Alzheimer's Disease to Study Aβ Proteotoxicity in the Digestive Tract.一种用于研究肠道中 Aβ 蛋白毒性的阿尔茨海默病新模型。
Int J Mol Sci. 2024 Feb 9;25(4):2105. doi: 10.3390/ijms25042105.
2
Amyloid β, Lipid Metabolism, Basal Cholinergic System, and Therapeutics in Alzheimer's Disease.淀粉样β、脂代谢、基底胆碱能系统与阿尔茨海默病的治疗。
Int J Mol Sci. 2022 Oct 11;23(20):12092. doi: 10.3390/ijms232012092.
3
Bacillus Calmette-Guérin in Immuno-Regulation of Alzheimer's Disease.卡介苗在阿尔茨海默病免疫调节中的作用

本文引用的文献

1
A 160-femtosecond optical image processor based on a conjugated polymer.基于共轭聚合物的 160 飞秒光图像处理器。
Science. 1994 Aug 26;265(5176):1215-6. doi: 10.1126/science.265.5176.1215.
2
STUDIES ON SUCCINATE-TETRAZOLIUM REDUCTASE SYSTEMS. III. POINTS OF COUPLING OF FOUR DIFFERENT TETRAZOLIUM SALTS.琥珀酸-四氮唑还原酶系统的研究。III. 四种不同四氮唑盐的偶联点
Biochim Biophys Acta. 1963 Nov 8;77:383-93. doi: 10.1016/0006-3002(63)90513-4.
3
The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?
Front Aging Neurosci. 2022 Jun 27;14:861956. doi: 10.3389/fnagi.2022.861956. eCollection 2022.
4
Monosialotetrahexosylganglioside Promotes Early Aβ42 Oligomer Formation and Maintenance.神经节苷脂 GM1 促进 Aβ42 寡聚体的早期形成和维持。
ACS Chem Neurosci. 2022 Jul 6;13(13):1979-1991. doi: 10.1021/acschemneuro.2c00221. Epub 2022 Jun 17.
5
Neurogenesis Is Increased in Human Neural Stem Cells by Aβ40 Peptide.β淀粉样肽（Aβ40）可增加人神经干细胞的神经发生。
Int J Mol Sci. 2022 May 22;23(10):5820. doi: 10.3390/ijms23105820.
6
Oligomeric and Fibrillar Species of Aβ42 Diversely Affect Human Neural Stem Cells.Aβ42 的寡聚体和纤维体物种对人神经干细胞有不同的影响。
Int J Mol Sci. 2021 Sep 2;22(17):9537. doi: 10.3390/ijms22179537.
7
Detrimental effects of long-term elevated serum uric acid on cognitive function in rats.长期血尿酸升高对大鼠认知功能的损害作用。
Sci Rep. 2021 Mar 24;11(1):6732. doi: 10.1038/s41598-021-86279-y.
8
Surface-Directed Structural Transition of Amyloidogenic Aggregates and the Resulting Neurotoxicity.淀粉样蛋白聚集物的表面导向结构转变及其导致的神经毒性。
ACS Omega. 2020 Feb 6;5(6):2856-2864. doi: 10.1021/acsomega.9b03671. eCollection 2020 Feb 18.
9
Cellular and Molecular Mediators of Neuroinflammation in Alzheimer Disease.阿尔茨海默病中神经炎症的细胞和分子介质
Int Neurourol J. 2019 Nov;23(Suppl 2):S54-62. doi: 10.5213/inj.1938184.092. Epub 2019 Nov 30.
10
Role of the Metal Center in the Modulation of the Aggregation Process of Amyloid Model Systems by Square Planar Complexes Bearing 2-(2'-pyridyl)benzimidazole Ligands.金属中心在含2-(2'-吡啶基)苯并咪唑配体的平面正方形配合物对淀粉样模型系统聚集过程调控中的作用。
Pharmaceuticals (Basel). 2019 Oct 12;12(4):154. doi: 10.3390/ph12040154.
核心阿尔茨海默病肽NAC形成淀粉样原纤维，这些原纤维可引发β-淀粉样蛋白并被其引发：NAC是神经退行性疾病的常见触发因素还是靶点？
Chem Biol. 1995 Mar;2(3):163-9. doi: 10.1016/1074-5521(95)90071-3.
4
Alpha 1-antichymotrypsin binding to Alzheimer A beta peptides is sequence specific and induces fibril disaggregation in vitro.α1-抗糜蛋白酶与阿尔茨海默病β淀粉样肽的结合具有序列特异性，并在体外诱导纤维解聚。
J Neurochem. 1993 Jul;61(1):298-305. doi: 10.1111/j.1471-4159.1993.tb03568.x.
5
Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?引发淀粉样蛋白的“一维结晶”：阿尔茨海默病和羊瘙痒病的一种致病机制？
Cell. 1993 Jun 18;73(6):1055-8. doi: 10.1016/0092-8674(93)90635-4.
6
Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25-35.
Neuroreport. 1993 May;4(5):523-6. doi: 10.1097/00001756-199305000-00015.
7
Amyloidogenicity of rodent and human beta A4 sequences.啮齿动物和人类β-淀粉样蛋白4序列的淀粉样蛋白生成性
FEBS Lett. 1993 Jun 14;324(2):231-6. doi: 10.1016/0014-5793(93)81399-k.
8
bcl-2 inhibits death of central neural cells induced by multiple agents.bcl-2抑制多种因素诱导的中枢神经细胞死亡。
Proc Natl Acad Sci U S A. 1993 May 15;90(10):4533-7. doi: 10.1073/pnas.90.10.4533.
9
The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease.β淀粉样蛋白的羧基末端对淀粉样蛋白形成的种子作用至关重要：对阿尔茨海默病发病机制的启示。
Biochemistry. 1993 May 11;32(18):4693-7. doi: 10.1021/bi00069a001.
10
Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid.载脂蛋白E：与可溶性阿尔茨海默病β-淀粉样蛋白的结合
Biochem Biophys Res Commun. 1993 Apr 30;192(2):359-65. doi: 10.1006/bbrc.1993.1423.