推测的容量性钙内流通道：果蝇瞬时受体电位通道的表达及脊椎动物同源物存在的证据
Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues.
作者信息
Petersen C C, Berridge M J, Borgese M F, Bennett D L
机构信息
Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, U.K.
出版信息
Biochem J. 1995 Oct 1;311 ( Pt 1)(Pt 1):41-4. doi: 10.1042/bj3110041.
Abstract
Capacitative calcium entry is a major pathway through which intracellular calcium stores are refilled after stimulation. It has been suggested that the protein encoded by the transient receptor potential (trp) gene expressed in Drosophila photoreceptors may be homologous with capacitative calcium entry channels. Expression of the trp gene product in Xenopus oocytes led to significant increases in calcium entry only when the intracellular calcium stores were depleted. Previous investigations have found trp to be uniquely expressed in Drosophila photoreceptors, but PCR cloning shows that homologous proteins exist in Calliphora, mouse brain and Xenopus oocytes. It is thus possible that capacitative calcium entry in Xenopus oocytes is mediated by a homologue of trp.
摘要
容量性钙内流是刺激后细胞内钙库重新充盈的主要途径。有人提出，果蝇光感受器中表达的瞬时受体电位（trp）基因编码的蛋白质可能与容量性钙内流通道同源。仅当细胞内钙库耗尽时，trp基因产物在非洲爪蟾卵母细胞中的表达才会导致钙内流显著增加。先前的研究发现trp仅在果蝇光感受器中特异性表达，但聚合酶链反应（PCR）克隆表明，丽蝇、小鼠脑和非洲爪蟾卵母细胞中存在同源蛋白。因此，非洲爪蟾卵母细胞中的容量性钙内流可能由trp的同源物介导。
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本文引用的文献
1
Calcium entry in Xenopus oocytes: effects of inositol trisphosphate, thapsigargin and DMSO.非洲爪蟾卵母细胞中的钙内流：肌醇三磷酸、毒胡萝卜素和二甲基亚砜的作用
Cell Calcium. 1993 Feb;14(2):101-10. doi: 10.1016/0143-4160(93)90080-p.
2
The signal for capacitative calcium entry.钙库调控性钙内流信号。
Cell. 1993 Oct 22;75(2):199-201. doi: 10.1016/0092-8674(93)80061-i.
3
Calcium influx and its control by calcium release.钙内流及其由钙释放所进行的调控。
Curr Opin Neurobiol. 1993 Jun;3(3):368-74. doi: 10.1016/0959-4388(93)90130-q.
4
Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger.肌醇三磷酸（InsP3）储存的耗尽通过一种磷酸酶和一种可扩散信使激活钙电流和钾电流。
Nature. 1993 Aug 26;364(6440):814-8. doi: 10.1038/364814a0.
5
Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.T淋巴细胞的丝裂原调节钙电流由细胞内钙库耗竭激活。
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6295-9. doi: 10.1073/pnas.90.13.6295.
6
Inositol trisphosphate and calcium signalling.肌醇三磷酸与钙信号传导
Nature. 1993 Jan 28;361(6410):315-25. doi: 10.1038/361315a0.
7
Activation of recombinant trp by thapsigargin in Sf9 insect cells.在 Sf9 昆虫细胞中，毒胡萝卜素对重组色氨酸（trp）的激活作用。
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8
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9
Receptor-mediated activation of recombinant Trpl expressed in Sf9 insect cells.在Sf9昆虫细胞中表达的重组Trpl的受体介导激活。
Biochem J. 1995 Jan 15;305 ( Pt 2)(Pt 2):605-11. doi: 10.1042/bj3050605.
10
The regulation of capacitative calcium entry by calcium and protein kinase C in Xenopus oocytes.非洲爪蟾卵母细胞中钙和蛋白激酶C对容量性钙内流的调节
J Biol Chem. 1994 Dec 23;269(51):32246-53.
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