亚铁螯合酶与存在于红系δ-氨基-γ-酮戊酸合酶mRNA中的铁反应元件结合。
Ferrochelatase binds the iron-responsive element present in the erythroid 5-aminolevulinate synthase mRNA.
作者信息
Ferreira G C
机构信息
Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa 33612, USA.
出版信息
Biochem Biophys Res Commun. 1995 Sep 25;214(3):875-8. doi: 10.1006/bbrc.1995.2368.
PMID:7575558
Abstract
Ferrochelatase, the terminal enzyme of the heme biosynthetic pathway, binds an iron-responsive element (IRE) present in the 5'untranslated region of the mRNA for erythroid 5-aminolevulinate synthase, the first enzyme of the heme biosynthetic pathway. This IRE-binding activity of ferrochelatase may play a critical role in the regulation of heme biosynthesis in differentiating erythrocytes.
摘要
亚铁螯合酶是血红素生物合成途径的末端酶，它与红系5-氨基酮戊酸合酶（血红素生物合成途径的第一个酶）mRNA的5'非翻译区中存在的铁反应元件（IRE）结合。亚铁螯合酶的这种IRE结合活性可能在分化中的红细胞血红素生物合成调节中起关键作用。
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